CROSSalive

Computes RNA secondary structure profile in vivo considering the effects of m6A methylation.

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RNA Sequences (FASTA format, please ensure that your sequences only contain A, C, G, T, and U. Do not use !@#$% etc.; the minimum required sequence length is 70 nucleotides and the maximum 30000.)

For very long sequences please try this version that allows submission via file upload.


Calculate RNA Structural Profile:


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Just trying out? Use the following examples:

Profile of the RepC, a region of Xist mildly affected by METLL3, showing a Pearson’s correlation of 0.30 with in vivo SHAPE data (Smola et al. 2016)

Profile of the whole sequence of NEAT1, a lincRNA whose structural profile was studied in presence of ADAR showing a AUC of 0.85 with PARS data (Solomon et al. 2017)