Tartaglia Lab Web Servers Portal
Contact, publications, and lab information.
Contact
For comments, suggestions and general inquiries or technical issues related to the web servers please contact Gian Gaetano Tartaglia.
About us
The RNA Systems Biology Lab
Previous Affiliations
Our articles
General information
Recent Press Releases
- Aptamers against Cancer (2026, Italian, Diaspro @ Repubblica)
- AI and molecule design (2026, Italian, time: 1:28:00)
- Giulia's aptamers for Pancreatic Cancer (2026, Italian, time: 6:45:00)
- Our EMBO workshop on iCLIP (E. Bechara; 2025)
- A new ERC PoC for ALS diagnostics (2025)
- RAI interview on ALS (Italian; 2025)
- ROBOT: A new tool to predict phase separation (2025)
- On the Nobel prize for Medicine (2024, Italian)
- Our great researcher L. Broglia (2024)
- Our EMBO workshop on iCLIP (E. Bechara; 2024)
- Identifying G quadruplex binding proteins - Nat Comm 2024
- Pathfinder on Bruillouin Microscopy and Phase Transitions - April 2023
- Aptamers against ALS - September 2022
- Predire Alzheimer usando il machine learning - June 2022
- Alzheimer's: ML approach for genetic predisposition - June 2022
- Unico compito di un virus è quello di riprodursi - January 2021
- Replication of SARS-Cov2 - November 2020
- From ERC, ASTRA study - November 2019
- Synergy Grant (2019)
- Messenger RNA Acts as a Chaperone - August 2019
- Genetic inheritance & X chromosome - May 2019
- RNAs in toxic protein aggregates - February 2019
- RNAs in neurodegenerative disease - January 2019
- Parkinson's disease - December 2017
- Frontiers in Molecular Biosciences section - August 2017
- Special PhD award to Davide Cirillo - July 2017
- H2020 grant on personalised medicine - June 2017
- Global Score algorithm [Italian] - April 2017
- Protein interactions with non-coding RNAs - February 2017
- Size matters and structure too - February 2017
- 'Blobs' inside cells - June 2016
- Transcription factors by company - December 2015
- Life@CRG - October 2015
- Cover of Molecular Biosystems - July 2014
- Human cells, proteins and RNA - April 2014
- Collaboration with Hospitals - December 2014
- catRAPID guide - July 2011
List of relevant publications
Recent Preprints
- Delli Ponti R, Vandelli A, Broglia L, Tartaglia GG Integrating RNA Structure and Protein Interactions to Uncover the Mechanisms of Viral and Cellular IRES Function
- BioRxiv 2025. Abstract · PDF
- Milordini G, Zacco E, Armaos A, Di Palma F, Masi M, Gilodi M, Rupert J, Broglia L, Varignani G, Oneto M, Scotto M, Marotta R, Girotto S, Cavalli A, Tartaglia GG Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment
- BioRxiv 2025. Abstract · PDF
- Zacco E, Gilodi M, Armaos A, Waldron FM, Rupert J, Shneider N, Gregory J, Tartaglia GG Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS
- BioRxiv 2025. Abstract · PDF
- Fiorentino J, Armaos A, Colantoni A, Tartaglia GG scRAPID-web: a web server for predicting protein-RNA interactions from single-cell transcriptomics
- BioRxiv 2025. Abstract · PDF
Methodology
- Fiorentino J#, Monti M#, Miltiadis-Vrachnos M, Bini G, Cutrufo T, Sanchez de Groot N, Armaos A, Tartaglia GG. catGRANULE 2.0: accurate predictions of liquid-liquid phase separating proteins at single amino acid resolution
- Genome Biology 2024. Abstract
- Fiorentino J, Armaos A, Colantoni A, Tartaglia GG. Prediction of protein-RNA interactions from single-cell transcriptomic data
- Nucleic Acids Research 2023. Abstract · PDF
- Schwarzl T#, Sahadevan S#, Lang B#, Miladi M, Backofen R, Huber W, Hentze MW*, Tartaglia GG*. Improved discovery of RNA-binding protein binding sites in eCLIP data using DEWSeq
- Nucleic Acids Research 2023. Abstract · PDF
- Armaos A #, Serra F#, Nunez-Carpintero I, Seo JI, Baca SC, Gustincich S, Valencia A, Freedman ML, Cirillo D*, Giambartolomei C *, Tartaglia GG * The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer
- Nature Communications 2023. Abstract · PDF
- Delli Ponti R, Broglia L*, Vandelli A, Armaos A, Torrent M, Sanchez N, Tartaglia GG. A high-throughput approach to predict A-to-I effects on RNA structure indicates a change of double-stranded content in non-coding RNAs
- IUBMB Life 2022. Abstract · PDF
- Zacco E#, Kantelberg O#, Milanetti E, Armaos A, Panei FP, Gregory J, Jeacock K, Clarke DJ, Chandran S, Ruocco G, Gustincich S, Horrocks MH, Pastore A, Tartaglia GG. Probing TDP-43 condensation using an in silico designed aptamer
- Nature Communications 2022. Abstract · PDF
- Miotto M, Armaos A, Di Rienzo L, Ruocco G, Milanetti M, Tartaglia GG. Thermometer: a webserver to predict protein thermal stability
- Bioinformatics 2022. Abstract · PDF
Applications
- Cipriano A#, Colantoni A#, Gomes D, Moqri M, Parker A, Caldwell M, Briganti F, Fiorentino J, Roncarolo MG, Baldini A, Weinacht KG, Tartaglia GG *, Sebastiano V *.
- Genome Biology 2024. Abstract · PDF
- Luige J#, Armaos A S#, Tartaglia GG*, Orom UA* Identification and prediction of G-quadruplex RNA-binding proteins with roles in transcription and phase separation
- Nucleic Acids Research 2024. Abstract · PDF
Reviews / general information
- Zacco E, Broglia L, Kurihara M, Monti M, Gustincich S, Pastore A, Plath K, Nagakawa S, Cerase A, Sanchez de Groot N, Tartaglia GG. RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding
- Chemical Reviews 2024. PDF
- Cerase A., Calabrese JM, Tartaglia GG. Phase separation drives X-chromosome inactivation.
- Nat Struct Mol Biol. 2022 PDF
- Haify SN, Botta-Orfila T, Hukema RK, Tartaglia GG. In silico, in vitro, and in vivo Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome.
- Front Mol Biosci. 2020 PDF
- Cerase A., Tartaglia GG. Long non-coding RNA-polycomb intimate rendezvous.
- Open Biol. 2020 PDF
- Colantoni A, Rupert J, Vandelli A, Tartaglia GG, Zacco E. Zooming in on protein-RNA interactions: a multi-level workflow to identify interaction partners.
- Biochem Soc Trans. 2020 PDF
- Dast A, Cid-Samper F, Bechara E, Tartaglia GG. RNA-centric approaches to study RNA-protein interactions in vitro and in silico.
- Methods. 2020 PDF
- Marchese D, Sanchez de Groot N, Lorenzo Gotor N, Livi CM, Tartaglia GG. Advances in the characterization of RNA-binding proteins.
- WIREs. 2016. Abstract · PDF
Book Chapters
- Marchese D, Livi CM, Tartaglia GG. A Computational Approach for the Discovery of Protein-RNA Networks.
- Methods Mol Biol. 2016;1358:29-39. doi: 10.1007/978-1-4939-3067-8_2. Abstract · PDF
- Bolognesi B, Tartaglia GG. Physicochemical principles of protein aggregation.
- Prog Mol Biol Transl Sci 2013. Abstract · PDF