cleverMachine

Two lists of proteins are compared using physicochemical features (e.g., hydrophobicity, RNA-binding propensities etc). The differential analysis is used to build models for the cleverClassifier

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Run mode
Normal run is recommended for majority of users and provides simplicity and robustness. Switching to expert mode enables multitude of additional features aimed at advanced users but at potential cost of increased computational time. Read more what could be done.


The expert mode allows submission of custom scales and enable cross-validating coverage score reporting. Please see documentation for detailed description.


Threshold calculation
Default is 0.75 and adaptive calculates multiple thresholds to find best dictimination. Selecting this option may prolong your submission.




Information extraction
By default, signal is extracted from the whole protein sequence. Selecting the peak detection mode filters the signal to only take into account regions with strong signal.




Smoothing window size







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Upload a Positive dataset (FASTA format, at least 10 and at most 104 sequences)

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Upload a Reference dataset (FASTA format, at least 10 and at most 104 sequences)

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Provide custom set of scales in format as defined


Just trying out? Use the following examples:

The human RNA-binding proteins
[Castello, A. et al. (2012) Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins. Cell, 149, 1393–1406]